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This practical guide shows biologists how to design reproducible experiments that have low bias, high precision, and results that are widely applicable. With specific examples using both cell cultures and model organisms, it shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. This is an ideal guide for anyone conducting lab-based biological research.
This is a wonderfully lucid introduction to experimental design, written by an author who is clearly aware of the pitfalls that exist for the unwary experimenter. Highly recommended.
– Prof. Dorothy Bishop, University of Oxford
It is really refreshing to come across a book that explicitly deals with experimental design and analysis. This new book clearly lays out what can and should be done and is written by an acknowledged expert and I have no doubt that this book will become a recommended read for all those contemplating undertaking work of this type.
– Prof. Roger Barker, University of Cambridge
This important textbook is a timely and highly useful contribution in the pressing quest to improve the robustness, rigor, and reproducibility of current biological and preclinical research. This volume is unique... [as] it is immensely readable and accessible even for those with little previous knowledge, in combining all relevant aspects in a practical, concise and comprehensive manner, and in its clear focus on factors that help to improve the quality of research.
– Prof. Ulrich Dirnagl, Charite University Hospital, Germany